Starting the season with a Community Shield victory over Leicester City and following up with an impressive 3-1 win at Bournemouth on the opening weekend of the Premier League, Man Utd bring renewed optimism into the campaign.
Two of their scorers on the south coast, Wayne Rooney and Juan Mata, have terrific records when previously playing the Saints.
Red Devils captain Rooney has five goals in nine league career starts against this opposition, while Spain international Mata boasts two in four Man Utd starts in the fixture.
Add in Anthony Martial and new threat Zlatan Ibrahimovic, coupled with the potential absence of top Southampton defender Jose Fonte, and this Manchester United price boost makes perfect sense.
Should the Red Devils fail to beat the Saint, then you’ll receive a £5 free bet as compensation. Bet now >>