Arsenal and Liverpool dropped points in Week 15, while Chelsea, Manchester City and Spurs all picked up vital wins.
Sunderland finally moved off the foot of the table with a 3-0 win against Hull, with Swansea taking their place despite holding Everton to a 1-1 draw at Goodison Park.
West Brom had the biggest winning margin of the week, beating Burnley 4-0 on Monday night.
Player of the week
West Brom's James Morrison topped the Week 15 scoring charts with 13 TFF points in West Brom's 4-0 win against Burnley. The midfielder scored and notched up two key contributions as Tony Pulis' side recorded back-to-back wins for the first time this season.
Manager of the week
John McAree from Ramsgate was the manager of the week, scooping himself a £200 first prize. His team, Novice Mac, chalked up a whopping 115 points, more than three times the average score of 31 points.
Team of the week
Three Sunderland and three West Brom players made the team of the week after they each recorded impressive home wins.
Manchester United 1-1 Arsenal
Arsenal extended their unbeaten run to 11 matches with a last-gasp draw at Old Trafford.
Juan Mata had opened the scoring for the Red Devils, expertly turning in a low pull-back from Ander Herrera.
Mesut Ozil and Alexis Sanchez failed to impress for the Gunners but the introduction of Olivier Giroud offered Arsene Wenger's side a new outlet and the French international headed in the equaliser after 89 minutes.
Star player: Olivier Giroud (£6.2m) 6 points
Giroud has yet to start a match this season and has only made six appearances from the bench. Despite that, he's still scored three times and it was his goal that rescued a crucial point on Saturday.
Crystal Palace 1-2 Manchester City
Manchester City recorded an important 2-1 win at Selhurst Park with Yaya Toure marking his return with a brace.
The Ivorian midfielder was making his first league start of the season and showed City what they've been missing with two goals, teed up by Nolito and Kevin de Bruyne.
Connor Wickham had equalised for the Eagles but it ultimately wasn't enough as Alan Pardew's side suffered their fifth straight league defeat in a row.
Star player: Yaya Toure (£5.0m) 12 points
It was a surprise to see Toure's name on the team sheet but the £5.0m rated midfielder seized the opportunity to chalk up his first TFF points for the season.
Everton 1-1 Swansea City
Swansea were denied just their second league win of the season as Everton snatched a dramatic late equaliser.
Bob Bradley's side went ahead courtesy of a penalty from Gylfi Sigurdsson but Seamus Coleman headed in after 89 minutes as the new Swans coach still seeks his first league win since being appointed.
The Toffees were poor in truth with both Romelu Lukaku and Yannick Bolasie looking particularly ineffective in attack.
Star player: Gylfi Sigurdsson (£4.6m) 7 points
Three goals and three key contributions now for the Icelandic midfielder who has been enjoying a fine run of points in recent weeks.
Southampton 0-0 Liverpool
Liverpool had to surrender their place at the top of the table after being held to a 0-0 draw by Southampton at St. Mary's.
Nathaniel Clyne, Sadio Mane and Dejan Lovren all started against their former club with Adam Lallana missing out through injury. But the ex-Saints contingent failed to break down Claude Puel's resolute defence which means the Reds are now a point behind the leaders, Chelsea.
Star player: Jose Fonte (£3.4m) 7 points
Southampton's captain was fantastic in central defence, organising the back four and keeping Coutinho, Firmino and Mane at bay.
Stoke City 0-1 Bournemouth
Bournemouth ended Stoke's six-game unbeaten run with a hard-fought 1-0 win at the Bet365 Stadium.
Callum Wilson was denied a clear penalty after being brought down by Ryan Shawcross in front of goal.
But the hard feelings were short-lived as on-loan Chelsea defender Nathan Ake headed in a Junior Stanislas free-kick.
Star player: Nathan Ake (£2.8m) 2 points
Ake made his first start of the season and rewarded the 0.2% of TFF managers that brought him into their side for Week 15 with a 12 point haul against Stoke.
Sunderland 3-0 Hull City
Jermain Defoe scored his 150th Premier League goal as Sunderland made it back-to-back wins for the first time this season.
Victor Anichebe scored his second and third goal in two games, making it a day to remember for David Moyes' side.
Conversely, Hull are in freefall having won just once in their last 10 games, losing eight times in that period. This result will be the most concerning for Mike Phelan, especially as the gap between the pair is now just two points.
Star player: Victor Anichebe (£3.4m) 12 points
Anichebe started just his second league game of the season and rewarded his manager's faith with a double at the Stadium of Light.
Watford 2-1 Leicester City
Watford bounced back from their 6-1 defeat at Liverpool in Week 13 by defeating champions Leicester City 2-1 at Vicarage Road.
Etienne Capoue opened the scoring for the home side after just 33 seconds, volleying in from Troy Deeney's header.
Roberto Pereyra then added a second just 12 minutes later, and although Riyad Mahrez pulling one back via the penalty spot, Walter Mazzarri's side held firm to remain eighth in the league table.
Star player: Roberto Pereyra (£3.2m) 10 points
Robert Pereyra has scored twice and produced four key contributions since his move from Juventus over the summer, making it 39 TFF points for the season.
Tottenham Hotspur 3-2 West Ham
Tottenham closed the gap on the top four with a thrilling 3-2 win against London-based rivals West Ham.
Michail Antonio opened the scoring for the visitors, his sixth headed goal of the season, before 20-year old Harry Winks equalised on his full Premier League debut.
Manuel Lanzini then put the Hammers back in front from the spot until two goals in the last minute from Harry Kane ensured Mauricio Pochettino's side snatched all three points.
Star player: Harry Kane (£6.8m) 12 points
To say Spurs missed Kane's goals when he was out injured is an understatement, but last season's top goal scorer is back and now has three goals in his last two appearances.
Middlesbrough 0-1 Chelsea
Chelsea are on fire. They've won their last six games to nil and are now top of the table, one point clear of second-placed Liverpool.
They're also dominating Telegraph Fantasy Football, with the seven top players in the six-week form guide plying their trade at Stamford Bridge.
Eden Hazard tops the chart on 50 points but it was his teammate Diego Costa that proved the difference on Sunday, volleying in his 10th league goal of the season.
Star player: Diego Costa (£6.7m) 7 points
Four Chelsea players scored 7 TFF points for the week but striker Diego Costa took all the headlines with his goal just before the break.
West Brom 4-0 Burnley
West Brom moved into the top half with a comprehensive 4-0 win over Burnley.
The Clarets have struggled away from home this season and found themselves 3-0 down after just 37 minutes with goals coming from the Scottish trio of Matt Phillips, James Morrison and Darren Fletcher.
Salomon Rondon then added the fourth after the break, making it back-to-back league wins for Tony Pulis' side.
Star player: Matt Phillips (£3.2m) 10 points
Matt Phillips scored his second goal in two game weeks, this time after just four minutes had expired.