There are 10 exciting fixtures to look forward to in Week 16 as Chelsea look to bring an end to Tottenham's unbeaten start to the season.
Elsewhere, Swansea will be hoping to record just their second league win of the season as they host out-of-form Crystal Palace and Liverpool will be aiming to return to the summit as they play hosts to Sunderland.
Struggling to decide who to pick for your Telegraph Fantasy Football team? Don't panic, we've cast our eye over all 10 fixtures and picked out the star player in each, as well as our weekly wildcard.
Burnley v Manchester City (12:30)
Manchester City and Burnley kick-off Week 16 in Saturday's lunchtime kick-off at Turf Moor.
Pep Guardiola's side come into the match off the back of a 1-1 draw in Monchengladbach on Wednesday night, while Burnley are still suffering from their 4-0 defeat at West Brom on Monday.
One to watch: Yaya Toure (£5.0m)
The Ivoirian midfielder was handed his first league start in Week 15 and didn't disappoint, scoring twice as City won 2-1 at Crystal Palace. He's still in just 0.4% of all teams and should keep his place in Guardiola's starting XI.
Coral new customer offer: Manchester City to beat Burnley - 50/1
Hull City v West Brom (15:00)
Hull have lost seven of their last eight matches, including a 3-0 defeat at Sunderland last time out.
West Brom, on the other hand, are flying, having won back-to-back matches including their 4-0 disposal of Burnley just five days ago.
One to watch: Salomon Rondon (£4.7m)
Rondon was West Brom's best player in Week 15 and will relish his chance to face a defence that's conceded 27 goals already this season - five more than any other team.
Leicester City v Middlesbrough (15:00)
Having qualified top of their Champions League group with a match to spare, Claudio Ranieri and his Leicester side are likely to turn their attention back to the Premier League.
They currently sit two points above the relegation zone, one place above their Week 16 opponents Middlesbrough, who themselves have won just once in their last 10 matches.
One to watch: Christian Fuchs (£3.6m)
An ever-present in Leicester's back four, Fuchs was instrumental in the Foxes' win against Brugge in midweek.
Liverpool v Sunderland (15:00)
On paper, this has a home win written all over it, but Sunderland do come into the game off the back of two consecutive wins and shouldn't be underestimated by Jurgen Klopp's side.
They themselves were held to a 0-0 draw by Southampton in Week 15 and could come up against an inspired Sunderland defence.
The league's top scorers are likely to continue with Coutinho, Firmino and Mane in attack, all of which are capable of scoring at any given moment.
One to watch: Sadio Mane (£5.0m)
Mane is a cheaper option than Coutinho and Firmino and also boasts three goals in his last four matches.
Swansea City v Crystal Palace (15:00)
Two sides that desperately need a win, Swansea are rock bottom having not won since the opening weekend while Palace have lost five in a row.
Alan Pardew's side are somehow still just outside the relegation zone and Bob Bradley is still yet to pick up his first win as the new Swans manager.
One to watch: Gylfi Sigurdsson (£4.6m)
Sigurdsson has been deployed in an advanced position in recent weeks and hasn't disappointed, scoring two and providing two key contributions in his last five outings.
Chelsea v Tottenham Hotspur (17:30)
The fixture of the weekend is at Stamford Bridge as high-flying Chelsea host rivals Tottenham.
The Blues ended Spurs title hopes in this fixture last season and would love nothing more than to be the side that gives Mauricio Pochettino his first league defeat of the campaign.
One to watch: Gary Cahill (£4.1m)
Cahill is top of the six-week form guide, the highest scoring defender in TFF 16/17 and was also on the scoresheet in the corresponding fixture last season.
Watford v Stoke City (12:00)
Watford and Stoke battle it out at midday on Sunday with the hosts looking to build on their current league position. They're eighth at the moment and are only looking up having beaten champions Leicester 2-1 in Week 15.
Stoke were unbeaten in six until they were beaten 1-0 at home to Bournemouth and will be looking to bounceback immediately with a positive result at the Hawthorns.
One to watch: Troy Deeney (£5.1m)
Watford's captain is due a goal, having not scored since Week 8. He's provided two key contributions recently and looks a strong choice in attack.
Arsenal v Bournemouth (14:15)
The Gunners haven't lost since the opening day of the season but have drawn three of their last four league matches.
Bournemouth are now in the top half having recorded an impressive 1-0 win at Stoke, where Nathan Ake headed in the winner on his first league start of the season.
One to watch: Carl Jenkinson (£3.2m)
With Hector Bellerin out injured, Jenkinson looks set to start at right back and could be set for points at both end of the pitch.
Manchester United v West Ham (16:30)
United have won just one of their last six league matches, a 3-1 win at Swansea.
West Ham are still 17th having been beaten by two last minute Harry Kane goals at White Hart Lane, which has left them just one point above the relegation zone.
One to watch: Paul Pogba (£5.7m)
The most expensive player in the world has shone in recent weeks, scoring one and adding a key contribution in his last two appearances.
Southampton v Everton (16:30)
Ronald Koeman makes the trip to his former employers and brings with him an Everton side struggling for form.
Southampton have had similarly patchy results but stopped Liverpool from scoring when the sides met last weekend.
One to watch: Charlie Austin (£4.6m)
Austin is Southampton's top point scorer so far, with 47, having scored five league goals in eight matches.
Thibaut Courtois (£3.2m)
Chelsea's shot stopper has kept six clean sheets in a row and could collect one more against a Spurs side that has struggled for goals all season.